Alterations in the ubiquitin-proteasome system (UPS) have been reported in several neurodegenerative disorders characterized by protein misfolding and aggregation. including the polylgutamine diseases. Machado-Joseph disease (MJD) or Spinocerebellar Ataxia type 3 is caused by a polyglutamine-encoding CAG expansion in the ATXN3 gene. which encodes a 42 kDa deubiquitinating enzyme (DUB). https://safeersappliancers.shop/product-category/aeg-dce731110m-touch-control-multifunction-a-rated-double-oven/